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LONDON — U.K. police have opened a fraud investigation into Britain’s Post Office over a miscarriage of justice that saw hundreds of postmasters wrongfully accused of stealing money when a faulty computer system was to blame.

The Metropolitan Police force said late Friday that it is investigating “potential fraud offences arising out of these prosecutions,” relating to money the Post Office received “as a result of prosecutions or civil actions” against accused postal workers.

Police also are investigating potential offenses of perjury and perverting the course of justice over investigations and prosecutions carried out by the Post Office.

Between 1999 and 2015, more than 700 post office branch managers were accused of theft or fraud because computers wrongly showed that money was missing. Many were financially ruined after being forced to pay large sums to the company, and some were convicted and sent to prison. Several killed themselves.

The real culprit was a defective computer accounting system called Horizon, supplied by the Japanese technology firm Fujitsu, that was installed in local Post Office branches in 1999.

The Post Office maintained for years that data from Horizon was reliable and accused branch managers of dishonesty when the system showed money was missing.

After years of campaigning by victims and their lawyers, the Court of Appeal quashed 39 of the convictions in 2021. A judge said the Post Office “knew there were serious issues about the reliability” of Horizon and had committed “egregious” failures of investigation and disclosure.

A total of 93 of the postal workers have now had their convictions overturned, according to the Post Office. But many others have yet to be exonerated, and only 30 have agreed to “full and final” compensation payments. A public inquiry into the scandal has been underway since 2022.

So far, no one from the publicly owned Post Office or other companies involved has been arrested or faced criminal charges.

Lee Castleton, a former branch manager who went bankrupt after being pursued by the Post Office for missing funds, said his family was ostracized in their hometown of Bridlington in northern England. He said his daughter was bullied because people thought “her father was a thief, and he’d take money from old people.”

He said victims wanted those responsible to be named.

“It’s about accountability,” Castleton told Times Radio on Saturday. “Let’s see who made those decisions and made this happen.”

The long-simmering scandal stirred new outrage with the broadcast this week of a TV docudrama, Mr. Bates vs the Post Office. It charted a two-decade battle by branch manager Alan Bates, played by Toby Jones, to expose the truth and clear the wronged postal workers.

Post Office Chief Executive Nick Read, appointed after the scandal, welcomed the TV series and said he hoped it would “raise further awareness and encourage anyone affected who has not yet come forward to seek the redress and compensation they deserve.”

A lawyer for some of the postal workers said 50 new potential victims had approached lawyers since the show aired on the ITV network.

“The drama has elevated public awareness to a whole new level,” attorney Neil Hudgell said. “The British public and their overwhelming sympathy for the plight of these poor people has given some the strength to finally come forward. Those numbers increase by the day, but there are so many more out there.”
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The Consumer Electronics Show, better known as CES, is back in Las Vegas [January 9 – 12] with more than 3,500 companies from around the globe showcasing the latest developments in artificial intelligence, health care, transportation and much more. VOA’s Julie Taboh gives us a preview. Video edit: Adam Greenbaum. Tina Trinh contributed to this report
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washington — Scientists have found a way to help Alzheimer’s drugs seep inside the brain faster — by temporarily breaching its protective shield.

The novel experiment was a first attempt in just three patients. But in spots in the brain where the new technology took aim, it enhanced removal of Alzheimer’s trademark brain-clogging plaque, researchers reported Wednesday.

“Our goal is to give patients a head start,” by boosting some new Alzheimer’s treatments that take a long time to work, said Dr. Ali Rezai of West Virginia University’s Rockefeller Neuroscience Institute, who led the study.

At issue is what’s called the blood-brain barrier, a protective lining in blood vessels that prevents germs and other damaging substances from leaching into the brain from the bloodstream. But it also can block drugs for Alzheimer’s, tumors and other neurologic diseases, requiring higher doses for longer periods for enough to reach their target inside the brain.

Now scientists are using a technology called focused ultrasound to jiggle temporary openings in that shield. They inject microscopic bubbles into the bloodstream. Next, they beam sound waves through a helmetlike device to a precise brain area. The pulses of energy vibrate the microbubbles, which loosen gaps in the barrier enough for medications to slip in.

Prior small studies have found the technology can safely poke tiny holes that seal up in 48 hours. Now Rezai’s team has gone a step further — administering an Alzheimer’s drug at the same time.

Some new Alzheimer’s drugs, on the market or in the pipeline, promise to modestly slow worsening of the mind-robbing disease. They’re designed to clear away a sticky protein called beta-amyloid that builds up in certain brain regions. But they require IV infusions every few weeks for at least 18 months.

“Why not try to clear the plaques within a few months?” Rezai said, his rationale for the proof-of-concept study.

3 patients, 1 drug, 6 months

His team gave three patients with mild Alzheimer’s monthly doses of one such drug, Aduhelm, for six months. Right after each IV, researchers aimed the focused ultrasound on a specific amyloid-clogged part of each patient’s brain, opening the blood brain-barrier so more of that day’s dose might enter that spot.

PET scans show patients’ amyloid levels before and after the six months of medication. There was about 32% greater plaque reduction in spots where the blood-brain barrier was breached compared to the same region on the brain’s opposite side, researchers reported in the New England Journal of Medicine.

This pilot study is elegant but too tiny to draw any conclusions, cautioned Dr. Eliezer Masliah of the National Institute on Aging.

Still, “it’s very exciting, compelling data,” added Masliah, who wasn’t involved with the research. “It opens the door for more extensive, larger studies, definitely.”

More testing on horizon

Rezai is about to begin another small test of a similar but better proven drug named Leqembi. Eventually, large studies would be needed to tell if combining focused ultrasound with Alzheimer’s drugs makes a real difference for patients.

Masliah said it’s also important to closely check whether speedier plaque reduction might increase the risk of a rare but worrisome side effect of these new drugs — bleeding and swelling in the brain.

Alzheimer’s isn’t the only target. Other researchers are testing if breaching the blood-brain barrier could allow more chemotherapy to reach brain tumors, and ways to target other diseases.
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